张建研究组主要从事脊椎动物早期胚胎发育与胚胎干细胞领域的工作。研究重点脊椎动物早期形态建成以及胚胎干细胞谱系建立分化的分子机理。我们采用斑马鱼、非洲爪蛙和小鼠等模式动物在分子、细胞和整体水平上研究早期发育过程中以下三个方面的内容：　 

1.母源因子对早期胚胎发育

2.原始生殖细胞发生的调控

3.小鼠细胞谱系建立和维持

1. Zhu, D., Gong, X., Miao, L., Fang, J. Zhang, J *. (2017) Efficient Induction of Syncytiotrophoblast Layer II Cells from Trophoblast Stem Cells by Canonical Wnt Signaling Activation. Stem Cell Reports. 9(6):2034-2049.

2. Miao L, Yuan Y, Cheng F, Fang J, Zhou F, Ma W, Jiang Y, Huang X, Wang Y,Shan L, Chen D, Zhang J*. (2017) Translation repression by maternal RNA binding protein Zar1 is essential for early oogenesis in zebrafish. Development 144(1):128-138.

3. Cheng F, Miao L, Wu Q, Gong X, Xiong J*, Zhang J*. (2016) Vinculin b deficiency causes epicardial hyperplasia and coronary vessel disorganization in zebrafish. Development.  143(19):3522-3531.

4. Fang J, Wang H, Miao L, Kuang X, Ma W, Wang C, Zhang J*, Xia G*. (2016) Involvement of Protein Acyltransferase ZDHHC3 in Maintaining Oocyte Meiotic Arrest in Xenopus laevis. Biol Reprod. 95(3):67.     

5. Ma WR, Zhang J*. (2015) Jag1b is essential for patterning inner ear sensory cristae by regulating anterior morphogenetic tissue separation and preventing posterior cell death. Development. 142(4):763-73.     

6. Su W, Fang J, Cheng F, Liu C, Zhou F, Zhang J*. (2013) RNF2/Ring1b negatively regulates p53 expression in selective cancer cell types to promote tumor development. Proc Natl Acad Sci USA. 110(5):1720-5. 

7. Liu C, Ma W, Su W, Zhang J*. (2012) Prdm14 acts upstream of islet2 transcription to regulate axon growth of primary motoneurons in zebrafish. Development. 139(24):4591-600.    

8. Wang HW, Fang JS, Kuang X, Miao LY, Wang C, Xia GL, King ML, Zhang J*.(2012) Activity of long-chain acyl-CoA synthetase is required for maintaining meiotic arrest in Xenopus laevis. Biol. Reprod. 87(3):74. 

9. Xu S, Cheng F, Liang J, Wu W, Zhang J*.(2012) Maternal xNorrin, a Canonical Wnt Signaling Agonist and TGF-b Antagonist, Controls Early Neuroectoderm Specification in Xenopus. PLOS Biol. 10(3): e1001286. doi:10.1371/journal.pbio.1001286.    

10. Zhang L, Zheng S, Wu H, Wu Y, Liu S, Fan M, Zhang J*. (2009) Identification of BLyS (B lymphocyte stimulator)...

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