主要研究方向

结合生物信息学和生化分子生物学，研究表观遗传和转录调控，专注于下列两个方面问题：

1，DNA甲基化等表观遗传修饰的发生和调控机制，以及在发育和疾病中起着关键的作用。

2，密码子偏好性对于基因在转录和翻译层面的调控，为同义突变引起的疾病提供理论基础。

1. Jingjing Fu, Yunkun Dang, Christopher Counter, Yi Liu, Codon usage regulates human KRAS expression at both transcriptional and translational levels. Journal of Biological Chemistry (2018) 293: 17929-17940.

2. Zhipeng Zhou#, Yunkun Dang#*, Mian Zhou, Haiyan Yuan, Yi Liu*, Codon usage biases co-evolve with transcription termination machinery to suppress premature cleavage and polyadenylation. Elife (2018) 7:e33569

3. Xiao Liu, Yunkun Dang, Toru Matsu-ura, Yubo He, Qun He, Christian I. Hong, Yi Liu, DNA Replication Is Required for Circadian Clock Function by Regulating Rhythmic Nucleosome Composition. Molecular Cell (2017) 67:1-11
   

4. Yunkun Dang#, Jiasen Cheng# , Xianyun Sun, Zhipeng Zhou, Yi Liu. Antisense transcription licenses nascent transcripts to be recognized by ERI-1 to mediate transcriptional gene silencing. Genes & Development, (2016) 30:2417-32.

5. Zhipeng Zhou#, Yunkun Dang#, Mian Zhou, Lin Li, Chien-Hung Yu, Jingjing Fu, She Chen, and Yi Liu. Codon Usage is an Important Determinant of Gene Expression Levels Largely Through its Effects on Transcription. PNAS (2016) E6117-E6125.

6. Chien-hung Yu#, Yunkun Dang#, Zhipeng Zhou#, Cheng Wu, Fangzhou Zhao, Matthew S. Sashs, Yi Liu. Codon Usage Influences the Local Rate of Translation Elongation to Regulate Co-translational Protein Folding. Molecular Cell (2015) 59:744-54（Cover article，special comment in Trend Biochem Sci (2015) 40:717-8）

7. Yunkun Dang, Liande Li, Wei Guo, Zhihong Xue, Yi Liu. Convergent transcription induces dynamic DNA methylation at disiRNA loci. PLoS Genetics (2013) 9(9): e1003761

8. Chang Ying Teng, Yunkun Dang, Jillian C. Danne, Ross F. Waller, Beverley R. Green. Genes of Dinoflagellates Are Transcribed by a Nuclear-Encoded Single-Subunit RNA Polymerase. PLoS One (2013) DOI: 10.1371/journal.pone.0065387

9. Yunkun Dang, Qiuying Yang, Zhihong Xue, Yi Liu. RNA interference in fungi: pathways, functions, and applications. Eukaryotic Cell (2011) 10: 1148-1155

10. Yunkun Dang, Beverley R. Green, Long transcripts from din...

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