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赵沛基


研究员/ pjzhao@ynu.edu.cn /微生物学

个人简历

1. 1993.09 ~ 1997.07bv伟德国际体育官方网站生物系生物技术专业，获理学学士学位；

2. 2001.09 ~ 2004.07 中国科学院昆明植物研究所，获理学硕士学位；

3. 2005.09 ~ 2008.07中国科学院昆明植物研究所，获理学博士学位；

4. 1997.07 ~ 2003.07 中国科学院昆明植物研究所，研究实习员；

5. 2003.07 ~ 2007.12中国科学院昆明植物研究所，助理研究员；

6. 2008.01 ~ 2016.04 中国科学院昆明植物研究所，副研究员；

7. 2012.09 ~ 2013.03 美国The University of Nebraska–Lincoln化学系, 访问学者；

8. 2009.01硕士研究生导师；

9. 2016.5 ~ 2016.11, bv伟德国际体育官方网站省部共建云南生物资源保护与利用国家重点实验室，副研究员；

10.  2016.12 ~ 至今, bv伟德国际体育官方网站省部共建云南生物资源保护与利用国家重点实验室，研究员


主要研究方向

围绕“微生物代谢产物生物合成”研究方向，运用天然产物化学、生化与分子生物学等学科知识与实验技术，开展微生物次生代谢产物的发现、生物合成及其调控机制的研究：

1. 微生物来源活性天然产物的分离鉴定；

2. 活性天然产物的生物合成。


主要论文

  1. Pei-Ji Zhao*, Yan-Long Yang, Liangchen Du, Ji-Kai Liu, Ying Zeng*. Elucidating the biosynthetic pathway for vibralactone, a novel pancreatic lipase inhibitor with a fused bicyclic β-lactone. Angewandte Chemie - International Edition. 2013, 52 (8): 2298-2302.

  2. Yan Lia, Pei-Ji Zhaoa,(aCo-author) Qian-Jin Kang, Juan Ma, Lin-Quan Bai*, Zi-Xin Deng. Dual carbamoylations on the polyketide and glycosyl moiety by Asm21 result in extended ansamitocin biosynthesis.Chemistry & Biology. 2011, 18 (12): 1571-1580.  

  3. Peiji Zhao, Linquan Bai*, Juan Ma, Ying Zeng, Lei Li, Yirong Zhang, Chunhua Lu, Huanqin Dai, Zhaoxian Wu, Yaoyao Li, Xuan Wu, Gang Chen, Xiaojiang Hao, Yuemao Shen*, Zixin Deng, Heinz G. Floss. Amide N-glycosylation by Asm25, an N-glycosyltransferase of ansamitocins. Chemistry & Biology. 2008, 15, 863-874.

  4. Yin-He Yang, Xiao-Li Fu, Liang-Qun Li, Ying Zeng, Cheng-Yun Li, Yi-Neng He, Pei-Ji Zhao*. Naphthomycins L−N, Ansamycin Antibiotics from Streptomyces sp. CS. Journal of Natural Products. 2012, 75, 1409-1413.

  5. Pei-Ji Zhao, Suo Gao, Li-Ming Fan, Jing-Lei Nie, Hong-Ping He, Ying Zeng, Yue-Mao Shen, Xiao-Jiang Hao*. Approach to the Biosynthesis of Atisine-type Diterpenoid Alkaloids.Journal of Natural Products.2009, 72(4): 645-659.

  6. Fei-Xue Yu, Zhe Li, Yao Chen, Yin-He Yang, Guo-Hong Li, Pei-Ji Zhao*. Four new steroids from the endophytic fungus Chaetomium sp. M453 derived of Chinese herbal medicine Huperzia serrata. Fitoterapia, 2017,117: 41–46.

  7. Fei-Xue Yu, Yao Chen, Yin-He Yang, Pei-Ji Zhao*. Four new dimeric spiro-azaplilone derivatives cochliodones E-H from the entophytic fungus Chaetomium sp. M336. Phytochemistry Letters, 2016, 16, 263-267.

  8. Jing Li, Jin Xie, Yin-He Yang, Xiao-Lian Li, Ying Zeng, Pei-Ji Zhao*. Pestalpolyols A–D, cytotoxic polyketides from Pestalotiopsis sp. cr013. Planta Medica, 2015, 81: 1285-1289.

  9. Yan-Mei Chen, Yin-He Yang, Xiao-Nian Li, Cheng Zou and Pei-Ji Zhao*. Diterpenoids from the Endophytic Fungus Botryosphaeria sp. P483 of the Chinese Herbal Medicine Huperzia serrate. Molecules. 2015, 20, 16924-16932.

  10. Jin Xie, Jing Li, Yin-He Yang, Yu-Hui Chen, Pei-Ji Zhao*. Two new ambuic acid analogs from Pestalotiopsis sp. cr013. Phytochemistry Letters, 2014, 10: 291-294.

  11. Juan Ma, Yue-Mao Shen, Ying Zeng, Pei-Ji Zhao*. Two New N-(O-Carbamoylglucopyranosyl)-N- dimethylansamitocins from Actinosynnema pretiosum. Helvetica Chimica Acta. 2012, 95(9):1630–1636.

  12. Jun-Tian Li, Xiao-Li Fu, Chun Tan, Ying Zeng, Qi Wang，Pei-Ji Zhao*. Two new chroman derivations from endophytic Penicillium sp. DCS523. Molecules. 2011, 16, 686-693.

  13. Xiao-Mei Zhang, Guo-Hong Li, Juan Ma, Ying Zeng, Wei-Guang Ma, Pei-Ji Zhao*. Endophytic fungus Trichothecium roseum LZ93 antagonizing pathogenic fungi In Vitro and its secondary metabolites. Journal of Microbiology. 2010, 48(6): 784-790.