个人简历       

1988年获四川大学学士；

1996年获University of Miami 博士学位；

1997-1999年，University of Miami 和Genentech Inc. 博士后；

2003-2016年，中国科学院遗传与发育生物学研究所， 研究员

2016年，bv伟德国际体育官方网站生命科学院副经理、生命科学研究中心副主任、教授（二级）

主要研究方向

我们实验室对发育生物学中的重要问题感兴趣，目前主要研究方向: 1）早期胚胎发育的调控（如：原始生殖细胞发生）；2）小鼠细胞谱系建立和维持。实验用模式动物包括斑马鱼，非洲爪蛙，和小鼠。 我们在研究中广泛运用遗传学，细胞生物学，生物化学的方法。

实验室成员和在读研究生

实验室成员：魏姝、颜芳、李朝晖、贲进

研究生：余俊旭

主要论文

1.Zhu, D., Gong, X., Miao, L., Fang, J. Zhang, J *. (2017) Efficient Induction of Syncytiotrophoblast Layer II Cells from Trophoblast Stem Cells by Canonical Wnt Signaling Activation. Stem Cell Reports. 9(6):2034-2049.

2. Miao L, Yuan Y, Cheng F, Fang J, Zhou F, Ma W, Jiang Y, Huang X, Wang Y,Shan L, Chen D, Zhang J*. (2017) Translation repression by maternal RNA binding protein Zar1 is essential for early oogenesis in zebrafish. Development 144(1):128-138.

3. Cheng F, Miao L, Wu Q, Gong X, Xiong J*, Zhang J*. (2016) Vinculin b deficiency causes epicardial hyperplasia and coronary vessel disorganization in zebrafish. Development. 143(19):3522-3531

4. Fang J, Wang H, Miao L, Kuang X, Ma W, Wang C, Zhang J*, Xia G*. (2016) Involvement of Protein Acyltransferase ZDHHC3 in Maintaining Oocyte Meiotic Arrest in Xenopus laevis. Biol Reprod. 95(3):67

5. Ma WR, Zhang J*. (2015) Jag1b is essential for patterning inner ear sensory cristae by regulating anterior morphogenetic tissue separation and preventing posterior cell death. Development. 142(4):763-73.

6. Su W, Fang J, Cheng F, Liu C, Zhou F, Zhang J*. (2013) RNF2/Ring1b negatively regulates p53 expression in selective cancer cell types to promote tumor development. Proc Natl Acad Sci USA. 110(5):1720-5.

7. Liu C, Ma W, Su W, Zhang J*. (2012) Prdm14 acts upstream of islet2 transcription to regulate axon growth of primary motoneurons in zebrafish. Development. 139(24):4591-600.

8. Wang HW, Fang JS, Kuang X, Miao LY, Wang C, Xia GL, King ML, Zhang J*.(2012) Activity of long-chain acyl-CoA synthetase is required for maintaining meiotic arrest in Xenopus laevis. Biol. Reprod. 87(3):74.

9. Xu S, Cheng F, Liang J, Wu W, Zhang J*.(2012) Maternal xNorrin, a Canonical Wnt Signaling Agonist and TGF-b Antagonist, Controls Early Neuroectoderm Specification in Xenopus. PLOS Biol. 10(3): e1001286. doi:10.1371/journal.pbio.1001286

10. Zhang L, Zheng S, Wu H, Wu Y, Liu S, Fan M, Zhang J*. (2009) Identification of BLyS (B lymphocyte stimulator), a non-myelin-associated protein, as a functional ligand for Nogo-66 receptor. J. Neurosci. 29(19):6348-52.